{"id":30,"date":"2023-07-04T15:08:52","date_gmt":"2023-07-04T14:08:52","guid":{"rendered":"http:\/\/tris.sambrownprojects.com\/?page_id=30"},"modified":"2024-08-14T01:47:58","modified_gmt":"2024-08-14T05:47:58","slug":"pain","status":"publish","type":"page","link":"https:\/\/www.trispharma.com\/innovation\/pain\/","title":{"rendered":"PAIN"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row full_width=&#8221;stretch_row&#8221; video_bg=&#8221;yes&#8221; video_bg_url=&#8221;\/wp-content\/uploads\/2023\/12\/pain-bg-video_1-lo-res-gradient.mp4&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;video-bl-bg&#8221; css=&#8221;.vc_custom_1723533864780{background-image: url(https:\/\/www.trispharma.com\/wp-content\/uploads\/2024\/08\/pain-bg-video_1-lo-res-gradient.jpg?id=3107) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243; el_class=&#8221;col-bl-bg pain-sp-left&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; css=&#8221;.vc_custom_1723614476262{padding-left: 50px !important;}&#8221;][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-inno text-white txt-pain-sm&#8221;]<\/p>\n<h1>The world needs <span class=\"org-text\">a new approach <\/span>to treating serious pain<\/h1>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-white&#8221;]Tris Pharma is working with urgency to develop a pipeline of differentiated compounds based on groundbreaking advances in the evolution of pain biology modulation. Our lead investigational compound, cebranopadol, is the world\u2019s first <span class=\"blue-highlight\">dual nociceptin\/orphanin FQ peptide (NOP) receptor and \u00b5-opioid peptide (MOP) receptor (dual-NMR) agonist,<\/span> and has the potential to offer gold-standard efficacy with minimized risk of detrimental side effects.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;subpage-nav hide-mobile&#8221;][vc_column]<div class=\"widget_sidebar_menu main-sidebar-menu wpb_custom_fa56fd63c3b694fcdb3812eb30a338f1\"><div class=\"sidebar-menu-wrap\"><ul id=\"menu-innovation-subnav\" class=\"sidebar-menu\"><li id=\"nav-menu-item-484\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/\">Overview<\/a><\/li>\n<li id=\"nav-menu-item-485\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/adhd\/\">ADHD<\/a><\/li>\n<li id=\"nav-menu-item-487\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/pain\/\">Pain<\/a><\/li>\n<li id=\"nav-menu-item-3138\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/addiction\/\">Addiction<\/a><\/li>\n<li id=\"nav-menu-item-486\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/innovation\/technologies\/\">Technologies<\/a><\/li>\n<\/ul><\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; el_class=&#8221;rw-first-pain&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column css=&#8221;.vc_custom_1711973820639{padding-top: 0px !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_row_inner content_placement=&#8221;bottom&#8221;][vc_column_inner el_class=&#8221;mb-width-max&#8221; width=&#8221;7\/12&#8243;][vc_column_text css=&#8221;.vc_custom_1713451866829{margin-bottom: 63px !important;}&#8221;]<\/p>\n<h2 style=\"text-align: center;\">The problem with pain<\/h2>\n<p>[\/vc_column_text][vc_single_image image=&#8221;2358&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; css=&#8221;.vc_custom_1717208385758{margin-bottom: 50px !important;}&#8221;][\/vc_column_inner][vc_column_inner el_class=&#8221;col-center-box&#8221; width=&#8221;5\/12&#8243; css=&#8221;.vc_custom_1714063758872{margin-bottom: 35px !important;}&#8221;][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-box-pain color-var-dark&#8221;]<\/p>\n<h5>Every year, millions of individuals suffer from moderate to severe pain due to surgeries, illnesses, trauma, burns and other injuries.<\/h5>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-box-pain color-var-black&#8221;]<\/p>\n<h5>Moderate to severe pain can have a devastating impact on all aspects of a patient\u2019s life, such as physical function, memory, cognition and attention, sleep and overall quality of life.<sup><a href=\"#notation\">1<\/a><\/sup><\/h5>\n<p>[\/vc_column_text][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-box-pain color-var-light&#8221;]<\/p>\n<h5>Unmanaged acute pain is not only debilitating in the short term, but can lead to chronic pain for millions.<sup><a href=\"#notation\">2-4<\/a><\/sup> In 2021, an estimated 51.6 million Americans experienced chronic pain.<sup><a href=\"#notation\">5<\/a><\/sup><\/h5>\n<p>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1716868885268{margin-bottom: 60px !important;}&#8221; el_class=&#8221;text-box-pain color-var-dark&#8221;]<\/p>\n<h5>Primarily targeting the MOP receptor, opioids are the only effective drugs for treating most moderate-to-severe pain patients. However, they can cause dangerous side effects, including addiction and respiratory depression.<\/h5>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; parallax=&#8221;content-moving&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;gradient-global bottom-collout-pain mob-footercallout bottom-collout&#8221;][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column_text css=&#8221;.vc_custom_1714557756976{padding-right: 30px !important;}&#8221; el_class=&#8221;text-white quote-width&#8221;]<\/p>\n<h2>The world needs a fundamentally different approach to treating serious pain.<\/h2>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][\/vc_column][\/vc_row][vc_row conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; css=&#8221;.vc_custom_1714063623143{padding-top: 55px !important;padding-bottom: 10px !important;}&#8221;][vc_column][vc_column_text css=&#8221;&#8221; el_class=&#8221;full-text-line&#8221;]<\/p>\n<h2>Answering the pressing call for effective pain management with a strong safety profile<\/h2>\n<p>At Tris, we are pioneering a fundamentally different approach to pain biology modulation: the <span class=\"blue-highlight\">dual-NMR agonist<\/span>.[\/vc_column_text][vc_column_text css=&#8221;&#8221;]<span class=\"blue-highlight\">Dual-NMR agonist<\/span> compounds have the potential to deliver gold-standard pain relief with a strong safety profile because they mimic the body\u2019s natural pain-modulation processes. By leveraging the body\u2019s innate coactivation of NOP and MOP, <span class=\"blue-highlight\">dual-NMR agonists<\/span> synergize the analgesic and safety characteristics of the NOP receptor with the analgesic advantages of the MOP receptor. Our investigational <span class=\"blue-highlight\">dual-NMR agonist<\/span>, cebranopadol, has been well-characterized, studied in approximately 2,000 patients, and is currently undergoing pivotal Phase 3 trials in various pain types.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;pn-adhd-half&#8221; css=&#8221;.vc_custom_1714037670033{margin-bottom: 70px !important;}&#8221;][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;mb-width-full&#8221;][vc_single_image image=&#8221;2365&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;mb-width-full&#8221;][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-white&#8221;]<\/p>\n<h2>Research into the potential safety advantages of the <span class=\"blue-highlight\">dual-NMR<\/span> mechanism is being supported by the NIH through a significant award<\/h2>\n<p>Because of cebranopadol\u2019s novel approach to pain modulation, we have generated promising preclinical data for the treatment of addiction. Based on these findings, Tris has been awarded up to $16.6 million over five years from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), to evaluate cebranopadol for the treatment of opioid and substance use disorder.[\/vc_column_text]<div class=\"porto-btn-ctn-left btn-glob btn-yellow sm-display\"><a class=\"porto-btn  vc_custom_1716867743255 porto-adjust-bottom-margin porto-btn-normal porto-btn-left-bg   wpb_custom_b78c3d864735b6f46402dc83321ac025  porto-btn-left \" title='Who We Are' rel='' href = \"\/tris-pharma-awarded-five-year-grant-of-up-to-16-6m-from-the-nihs-national-institute-on-drug-abuse-to-advance-cebranopadol-for-the-treatment-of-opioid-use-disorder\/\"  data-hover=\"#f29557\" data-border-color=\"\" data-bg=\"\" data-hover-bg=\"#ffffff\" data-border-hover=\"\" data-shadow-click=\"none\" data-shadow=\"\" style=\"border:none;color: #ffffff;\"><span class=\"porto-btn-hover\" style=\"background-color:#ffffff\"><\/span><span class=\"porto-btn-data porto-btn-text \" >Learn More<\/span><\/a><\/div>[vc_column_text css=&#8221;&#8221; el_class=&#8221;pain-sm-text&#8221;]This research is supported by the National Institute on Drug Abuse of the National Institutes of Health under Award Number UG3DA059285. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1700742620230{padding-bottom: 55px !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_id=&#8221;notation&#8221; el_class=&#8221;rw-notation&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1714106567074{margin-bottom: 0px !important;}&#8221; el_class=&#8221;notation-typo&#8221;]<sup>1 <\/sup>Phillips JK, Ford MA, Bonnie RJ. Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use. <em>National Academies of Sciences, Engineering, and Medicine.<\/em> July 2017.<br \/>\n<sup>2 <\/sup>Mura P, Serra E, Marinangeli F, et al. Prospective study on prevalence, intensity, type, and therapy of acute pain in a second-level urban emergency department. <em>J Pain Res.<\/em> 2017;10:2781-2788.<br \/>\n<sup>3 <\/sup>Garimella V, Cellini C. <em>Clin Colon Rectal Surg.<\/em> 2013;26(3):191-196.<br \/>\n<sup>4 <\/sup>Glare P, et al. <em>Lancet.<\/em> 2019;13:1537-1546.<br \/>\n<sup>5 <\/sup>Rikard SM, et al. Chronic Pain Among Adults \u2013 United States, 2019-2021. <em>MMWR.<\/em> April 2023: 72(15):379-385.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; parallax=&#8221;content-moving&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;gradient-global bottom-collout&#8221;][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column_text css=&#8221;.vc_custom_1716920900796{padding-right: 30px !important;}&#8221; el_class=&#8221;text-white quote-width&#8221;]<\/p>\n<h2>Our mission is to bring transformative pain management solutions to patients suffering from acute, chronic and neuropathic pain.<\/h2>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row full_width=&#8221;stretch_row&#8221; video_bg=&#8221;yes&#8221; video_bg_url=&#8221;\/wp-content\/uploads\/2023\/12\/pain-bg-video_1-lo-res-gradient.mp4&#8243; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;video-bl-bg&#8221; css=&#8221;.vc_custom_1723533864780{background-image: url(https:\/\/www.trispharma.com\/wp-content\/uploads\/2024\/08\/pain-bg-video_1-lo-res-gradient.jpg?id=3107) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}&#8221;][vc_column width=&#8221;1\/2&#8243;][\/vc_column][vc_column width=&#8221;1\/2&#8243; el_class=&#8221;col-bl-bg pain-sp-left&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; 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