{"id":79,"date":"2023-07-10T11:30:09","date_gmt":"2023-07-10T10:30:09","guid":{"rendered":"https:\/\/tris.sambrownprojects.com\/?page_id=79"},"modified":"2024-05-29T14:10:12","modified_gmt":"2024-05-29T13:10:12","slug":"pain","status":"publish","type":"page","link":"https:\/\/www.trispharma.com\/pipeline\/pain\/","title":{"rendered":"Pain Pipeline"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row el_class=&#8221;subnav-shortcode&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1692361090068{margin-bottom: 0px !important;}&#8221;]<div class=\"porto-block\" data-id=\"1137\">[vc_row full_width=\"stretch_row\" wrap_container=\"yes\" video_bg=\"yes\" video_bg_url=\"\/wp-content\/uploads\/2023\/07\/Interior_WhoWeAre-Optimized.mp4\" conditional_render=\"%5B%7B%22value_role%22%3A%22administrator%22%7D%5D\" el_class=\"subpage-banner subpage-who-we-are\"][vc_column width=\"1\/2\"][vc_custom_heading field_dynamic_source=\"post_info\" font_container=\"tag:h1|text_align:left\" use_theme_fonts=\"yes\" enable_field_dynamic=\"true\" field_dynamic_content=\"post_title\"][\/vc_column][vc_column width=\"1\/2\"][\/vc_column][\/vc_row][vc_row full_width=\"stretch_row\" wrap_container=\"yes\" conditional_render=\"%5B%7B%22value_role%22%3A%22administrator%22%7D%5D\" el_class=\"subpage-nav hide-mobile current-topnav\"][vc_column]<div class=\"widget_sidebar_menu main-sidebar-menu wpb_custom_fa56fd63c3b694fcdb3812eb30a338f1\"><div class=\"sidebar-menu-wrap\"><ul id=\"menu-subnav-pipeline\" class=\"sidebar-menu\"><li id=\"nav-menu-item-1030\" class=\"active-pipline menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/pipeline\/\">Overview<\/a><\/li>\n<li id=\"nav-menu-item-2639\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/pipeline\/adhd\/\">ADHD Pipeline<\/a><\/li>\n<li id=\"nav-menu-item-2641\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/pipeline\/pain\/\">Pain Pipeline<\/a><\/li>\n<li id=\"nav-menu-item-2640\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/pipeline\/other-cns-disorders\/\">Other CNS Disorders<\/a><\/li>\n<li id=\"nav-menu-item-1031\" class=\"menu-item menu-item-type-post_type menu-item-object-page  narrow \"><a href=\"https:\/\/www.trispharma.com\/pipeline\/clinical-publications\/\">Clinical Publications<\/a><\/li>\n<\/ul><\/div><\/div>[\/vc_column][\/vc_row]<\/div>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1691510599033{margin-bottom: 0px !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;subpage-first-row&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1714557205353{margin-bottom: 0px !important;}&#8221;]<\/p>\n<h2>Our mission is to bring transformative pain management solutions to patients suffering from acute, chronic and neuropathic pain.<\/h2>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1691572922952{margin-bottom: 0px !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;subpage-first-row-text&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1713450583744{margin-bottom: 0px !important;}&#8221;]Our pipeline of next-generation therapeutics focuses on using novel science to generate unrivaled clinical outcomes. Every step of the way, we work closely with global regulatory agencies to ensure that the safety, efficacy and quality of our pain medications meet \u2013 and ideally exceed \u2013 standards.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;rw-darkblue&#8221;][vc_column conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column_text el_class=&#8221;text-white phase-sp&#8221;]<\/p>\n<h6>PHASE 3<\/h6>\n<p>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1691894817615{margin-bottom: 30px !important;}&#8221; el_class=&#8221;text-white border-phase&#8221;][\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1716869317539{margin-bottom: 0px !important;}&#8221; el_class=&#8221;text-white&#8221;]<\/p>\n<h2>Cebranopadol<\/h2>\n<p><em>The first and only investigational <span class=\"blue-highlight\">dual nociceptin\/orphanin FQ peptide (NOP) receptor and \u00b5-opioid peptide (MOP) receptor (dual-NMR) agonist<\/span><\/em><\/p>\n<p>Cebranopadol offers a unique approach to pain biology modulation through its first-in-class mechanism: the <span class=\"blue-highlight\">dual-NMR agonist.<\/span> Its profile has been well-characterized in more than 30 efficacy and safety clinical trials involving approximately 2,000 patients to date. Data from these studies show cebranopadol:<\/p>\n<ul>\n<li>is potentially as effective at treating acute, chronic and neuropathic pain as the most potent therapies on the market today.<\/li>\n<li>has potential to not cause the detrimental side effects seen with opioids such as physical dependence and misuse\u200b.<\/li>\n<li>may have significantly lower risk of overdose from respiratory depression.<\/li>\n<li>is well-tolerated and has simple, once-a-day dosing that will not require adjustment for food, renal or hepatic impairment, or tapering at the end of therapy.<\/li>\n<\/ul>\n<p>Because of its unique mechanism of action, cebranopadol has the potential to significantly change the pain-relief landscape. Notably, the FDA has granted Fast Track Designation to cebranopadol for chronic low back pain. If approved, this investigational therapy could become the first and only pain relief treatment with the demonstrated ability to provide efficacy equivalent to traditional single-receptor agents and significantly less potential for misuse or risk of physical dependence, addiction or overdose.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; equal_height=&#8221;yes&#8221; content_placement=&#8221;middle&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;rw-lightblue&#8221;][vc_column conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column_text el_class=&#8221;text-white phase-sp&#8221;]<\/p>\n<h6>PHASE 2<\/h6>\n<p>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1691894817615{margin-bottom: 30px !important;}&#8221; el_class=&#8221;text-white border-phase&#8221;][\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1713450735816{margin-bottom: 0px !important;}&#8221; el_class=&#8221;text-white&#8221;]<\/p>\n<h2>TRN-261<\/h2>\n<p><em>A first-in-class analgesic in development for multiple indications within acute and chronic pain<\/em><\/p>\n<p>TRN-261 is a peptide molecule that has been extensively studied clinically in non-pain indications and has shown strong potential to deliver effective pain relief across multiple acute and chronic types. By combining the molecule\u2019s novel pain mechanism and safety profile with our unique formulation capabilities, TRN-261 has the potential to be a breakthrough treatment for millions of patients.[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row&#8221; wrap_container=&#8221;yes&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;gradient-global bottom-collout-pp mob-footercallout&#8221;][vc_column width=&#8221;1\/2&#8243;][vc_column_text css=&#8221;&#8221; el_class=&#8221;text-white quote-width&#8221;]<\/p>\n<h2>Our mission is to bring transformative pain management solutions to patients suffering from acute, chronic and neuropathic pain.<\/h2>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/2&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row el_class=&#8221;subnav-shortcode&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1692361090068{margin-bottom: 0px !important;}&#8221;][\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1691510599033{margin-bottom: 0px !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;subpage-first-row&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1714557205353{margin-bottom: 0px !important;}&#8221;] Our mission is to bring transformative pain management solutions to patients suffering from acute, chronic and neuropathic pain. [\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1691572922952{margin-bottom: 0px !important;}&#8221; conditional_render=&#8221;%5B%7B%22value_role%22%3A%22administrator%22%7D%5D&#8221; el_class=&#8221;subpage-first-row-text&#8221;][vc_column][vc_column_text css=&#8221;.vc_custom_1713450583744{margin-bottom: 0px !important;}&#8221;]Our pipeline of next-generation therapeutics focuses on using novel science to generate unrivaled clinical outcomes. 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